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충치에 사용하는 요오드 살균제
제목 충치에 사용하는 요오드 살균제
작성자 요오드 연구소 (ip:)
  • 작성일 2021-08-09
  • 추천 추천 하기
  • 조회수 159
  • 평점 0점

충치에 사용하는 요오드 살균제


저자: Peter Milgrom, DDS


치아 우식증의 증상

요오드 (I2)는 강력하고 신속한 항균작용을 하며 플라그(dental plaque biofilm)도 투과할 수 있다15예방적 치과치료 후 2% I2-KI(요오드-요오드화칼륨용액을 즉시 또는 3-5일 후 사용하면 치아표면(tooth fissure)  proximal surface 치태 및 침의 충치균(S. mutans) 수치를 유의하게 감소시킨다. proximal plaque 와 침의 충치균 억제효과는 20-24주간 지속된다. fissure plaques 4주간 유의하게 억제되지만 식이조절을 중단하면 서서히 본래수치로 돌아온다16.

 

I2는 또한 mutans streptococci(충치균)의 글라이코실전달효소(glucosyltransferase) 발현 및 생성을 억제하여 충치균이 치면(tooth surfaces)에 결합하는 것을 방해한다17클라이코실전달효소(glucosyltransferase)는 박테리아균이 치태에 점착되는 것을 중개하는 역할에 중요하게 관여하는 병독성 결정소(virulence determinants)인 것으로 알려져 있다.

 

미취학 아동과 취학아동들을 대상으로 한 두 실험에서 불소 바니시(fluoride varnish)보다 포비돈 요오드(베타딘)와 불화나트륨(NaF) 바니쉬를 함께 사용한 경우 충치를 줄이는데 더 효과적인 것으로 나타났다18,19포비돈 요오드는 접촉시 효과를 나타내며 색소침착이 되지 않고 맛이 나쁘지 않다.

 

15. Tanzer JM, Slee AM, Kamay B, Scheer, E. In vitro evaluation of three iodine-containing compounds as antiplaque agents. Antimicrob Agents Chemother 12:107-113, 1977.

16. Caufi eld PW, Gibbons RJ. Suppression of Streptococcus mutans in the mouths of humans by a dental prophylaxis and topically-applied iodine. J Dent Res 58(4):1317-26, 1979.

17. Furiga A, Dols-Lafargue M, Heyraud A, Chambat G, Lonvaud-Funel A, Badet C. Eff ect of antiplaque compounds and mouth rinses on the activity of glucosyltransferases from Streptococcus sobrinus and insoluble glucan production. Oral

Microbiol Immunol 23:391–400, 2008.

18. Tut OK, Milgrom PM. Topical iodine and fluoride varnish combined is more eff ective than fl uoride varnish alone for protecting erupting fi rst permanent molars: a retrospective cohort study. J Public Health Dent 70(3):249-52, 2010.

19. Milgrom PM, Tut OK, Mancl LA. Topical iodine and fluoride varnish eff ectiveness in the primary dentition: A quasiexperimental study. J Dent Child 78(3):102-106, 2011.

20. Rethman MP, Beltrán-Aguilar ED, Billings RJ, Hujoel PP, Katz BP, Milgrom P, Sohn W, Stamm JW, Watson G, Wolff M, Wright JT, Zero D, Aravamudhan K, Frantsve-Hawley J, Meyer

DM. Nonfl uoride caries-preventive agents: executive summary of evidence-based clinical recommendations. J Am Dent Assoc 142(9):1065-1071, 2011.

 

 

 

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Management of Patients with Active Caries


Peter Milgrom, DDS

Antiseptics

http://www.cambracoalition.org/sites/default/files/Management%20of%20Patients%20with%20Active%20Caries%20-%20Milgrom%20-%20CDA%20Journal%20July%202014.pdf

 

Iodine (I2) is among the most potent of bactericidal agents, and its action is rapidly bactericidal. I2 has excellent penetration into intact dental plaque biofilm and its bactericidal and penetrability characteristics make it an excellent choice for dental use. A single dental prophylaxis followed by application of a 2% I2-KI solution immediately and again at three and five days following the single prophylaxis significantly reduced S. mutans levels in tooth fissure and proximal surface plaques and saliva of dental assistants and dental hygiene students. Reductions of S. mutans persisted 20-24 weeks in proximal plaque and saliva; fissure plaques were significantly suppressed for four weeks but gradually returned to baseline in the absence of dietary restrictions.


The second argument in favor of I2 is that it is known to impact the ability of S. mutans to bind to tooth surfaces by disrupting the expression and production of glucosyltransferase by the mutans streptococci. Glucosyltransferase made by them is critically involved in mediation of adherence of these bacteria to the teeth biofilm and is established to be a potent virulence determinant.


Two studies, in high-risk preschoolers and school-age children, have shown that the combination of readily available povidone iodine plus sodium fluoride (NaF) varnish applied sequentially at the same appointment is more effective in reducing caries than fluoride varnish alone. Povidone iodine is nonstaining and does not taste or feel bad. It works on contact.





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